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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 418793Generated: October 27, 2026

2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane → Ethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoro methyl)pentyl]amino}-1h-indazol-1-yl)benzoate

https://huagongshe.com/reaction/418793

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxiraneHCID 16099239—
ReactantEthyl 3-(4-amino-1H-indazol-1-yl)benzoateHCID 57615935—
ProductEthyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoro methyl)pentyl]amino}-1h-indazol-1-yl)benzoateHCID 57615933—

Reaction Steps

Prepared similarly to Example 1 from racemic 2-{2-[5-fluoro-2-(methyloxy)phenyl]-2-methylpropyl}-2-(trifluoromethyl)oxirane and ethyl 3-(4-amino-1H-indazol-1-yl)benzoate (Intermediate 6).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08093281B2
Source datasetuspto-grants-2012_01
ORD IDord-2db637197d0147de81398715378b8c9d
Source noteuspto-grants-2012_01