1-(2,4-Difluorophenyl)-1H-indazol-4-amine → 2-({[1-(2,4-Difluorophenyl)-1h-indazol-4-yl]amino}methyl)-4-(2,3-dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-pentanol

Participants

Role	Name	HCID	Charge
Reactant	1-(2,4-Difluorophenyl)-1H-indazol-4-amine	HCID 57615963	—
Reactant	7-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran	HCID 57775518	—
Product	2-({[1-(2,4-Difluorophenyl)-1h-indazol-4-yl]amino}methyl)-4-(2,3-dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-pentanol	HCID 57615951	—

Reaction Steps

Prepared similarly to Example 1 from racemic 7-{1,1-dimethyl-2-[2-(trifluoromethyl)-2-oxiranyl]ethyl}-2,3-dihydro-1-benzofuran (which may be prepared according to WO 04/063163) and 1-(2,4-difluorophenyl)-1H-indazol-4-amine (Intermediate 4).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093281B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-fdbfcd9d4b414233a5ad0aa80a0db44e
Source note	uspto-grants-2012_01