2-Fluoro-5-formylpyridine → 4-tert-Butyl-N-[5-chloro-2-(6-fluoro-pyridine-3-carbonyl)-pyridin-3-yl]-N-methoxymethyl-benzenesulfonamide

HRID 419208

Reaction equation

HRID 419208 reaction equation
Br[C:2]1[C:7]([N:8]([CH2:22][O:23][CH3:24])[S:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:6][C:5]([Cl:25])=[CH:4][N:3]=1.[F:26][C:27]1[N:32]=[CH:31][C:30]([CH:33]=[O:34])=[CH:29][CH:28]=1>>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([S:9]([N:8]([C:7]2[C:2]([C:33]([C:30]3[CH:31]=[N:32][C:27]([F:26])=[CH:28][CH:29]=3)=[O:34])=[N:3][CH:4]=[C:5]([Cl:25])[CH:6]=2)[CH2:22][O:23][CH3:24])(=[O:11])=[O:10])=[CH:13][CH:14]=1)([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 164142462-Fluoro-5-formylpyridineHCID 57942088N-(2-bromo-5-chloro-pyridin-3-yl)-4-tert-butyl-N-methoxymethyl-benzenesulfonamide

Product 1

HCID 579425634-tert-Butyl-N-[5-chloro-2-(6-fluoro-pyridine-3-carbonyl)-pyridin-3-yl]-N-methoxymethyl-benzenesulfonamideYield 38%

Procedure

4-tert-Butyl —N-[5-chloro-2-(6-fluoro-pyridine-3-carbonyl)-pyridin-3-yl]-N-methoxymethyl-benzenesulfonamide was prepared from N-(2-bromo-5-chloro-pyridin-3-yl)-4-tert-butyl-N-methoxymethyl-benzenesulfonamide and 6-fluoro-pyridine-3-carbaldehyde using the procedure described in examples 35 and 36.

Sources & evidence

ORD record
ord-cd55db13bc22436fb98325c56f5b755c
Source dataset
uspto-grants-2012_01
Patent number
US08093247B2

Linked notes

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