2-Methoxy-5-nitro-3-phenylpyridine → 6-Methoxy-5-phenylpyridin-3-amine
Reaction equation
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][C:6]([N+:15]([O-])=O)=[CH:5][N:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([NH2:15])=[CH:7][C:8]=1[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 2-methoxy-5-nitro-3-phenylpyridine (0.43 mmol, 0.1 g) and Pd/C 10% (0.14 mmol, 0.015 g) in ethanol (2 ml) was stirred for 16 hours under hydrogen atmosphere. The catalyst was filtered off and the solid thoughtfully washed with warm ethanol. The filtrate was evaporated affording 0.085 g (98% of yield) of the expected product.
Workup
- filtrationThe catalyst was filtered off
- washthe solid thoughtfully washed with warm ethanol
- customThe filtrate was evaporated
- customaffording
Sources & evidence
- ORD record
- ord-468195bcbf8a4469b45bd7e69b97c2f4
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536165B2
Reaction notes
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