(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester → (2S,4S)-1-tert-butyl 2-methyl 4-(8-chloro-7-methoxy-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)quinolin-4-yloxy)pyrrolidine-1,2-dicarboxylate
Reaction equation
[CH3:1][O:2][C:3](=[O:17])[C@@H:4]1[CH2:8][C@@H:7]([OH:9])[CH2:6][N:5]1[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11].[Cl:18][C:19]1[C:20]([O:39][CH3:40])=[CH:21][CH:22]=[C:23]2[C:28]=1[N:27]=[C:26]([N:29]1[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[N:30]1)[CH:25]=[C:24]2O.C(OC(C(CCC=CCCCCCCCCCC)CCC)=O)C>>[Cl:18][C:19]1[C:20]([O:39][CH3:40])=[CH:21][CH:22]=[C:23]2[C:28]=1[N:27]=[C:26]([N:29]1[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:35])[F:36])=[N:30]1)[CH:25]=[C:24]2[O:9][C@@H:7]1[CH2:6][N:5]([C:10]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:11])[C@H:4]([C:3]([O:2][CH3:1])=[O:17])[CH2:8]1Participants
4
