Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromophenol | HCID 11563 | — |
| Reactant | Bromocyclopropane | HCID 78037 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Bromo-3-cyclopropoxybenzene | HCID 57416951 | 83.1% |
Reaction Steps
A mixture of 3-bromophenol (4.80 mmol, 0.83 g), bromocyclopropane (27.71 mmol, 2.22 ml), K2CO3 (23.15 mmol, 3.2 g) in DMF (18 ml) was heated at 180° C. for 8 hours in a microwave oven. Water and diethyl ether were added and the organic phase was evaporated affording 0.85 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08536165B2 |
|---|
| Source dataset | uspto-grants-2013_09 |
|---|
| ORD ID | ord-34589bfa5226443b9088b777e4c58fe9 |
|---|
| Source note | uspto-grants-2013_09 |
|---|
