5-Amino-2-chloropyridine → 6-(2-Fluorophenyl)pyridin-3-amine

HRID 42032

Reaction equation

HRID 42032 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1B(O)O>>[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 793055-Amino-2-chloropyridineHCID 27343542-Fluorophenylboronic acid

Product 1

HCID 189555756-(2-Fluorophenyl)pyridin-3-amineYield 31%

Procedure

Obtained (0.210 g, yield 31%) following the procedure described in Intermediate 39, starting with 6-chloropyridin-3-amine (3.50 mmol, 0.45 g), 2-fluorophenylboronic acid (6.94 mmol, 0.97 g).

Workup

  1. customObtained (0.210 g, yield 31%)

Sources & evidence

ORD record
ord-0c947ad444534faea050dadbc655e2c8
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Linked notes

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