6-Bromopyridin-3-amine → 6-(2-(Trifluoromethyl)phenyl)pyridin-3-amine

Reaction equation

Br[C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1B(O)O>>[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6428116-Bromopyridin-3-amine

HCID 27343872-(Trifluoromethyl)benzeneboronic acid

Product 1

HCID 665212636-(2-(Trifluoromethyl)phenyl)pyridin-3-amineYield 59%

Procedure

Obtained (2.05 g, yield 59%) following the procedure described in Intermediate 27, starting with 6-bromopyridin-3-amine, 2-(trifluoromethyl)phenylboronic acid.

Workup

customObtained (2.05 g, yield 59%)

Sources & evidence

ORD record: ord-ffd306596ef8463987e9e68d2ef78b8c
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08536165B2

Reaction notes

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