6-Bromopyridin-3-amine → 3',5'-Difluoro-2,4'-bipyridin-5-amine

HRID 42048

Reaction equation

HRID 42048 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.[F:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([F:29])[C:15]=1[Sn](CCCC)(CCCC)CCCC>>[F:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([F:29])[C:15]=1[C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 6428116-Bromopyridin-3-amineHCID 164271233,5-Difluoro-4-(tributylstannyl)pyridine

Product 1

HCID 584158393',5'-Difluoro-2,4'-bipyridin-5-amineYield 50%

Procedure

Obtained (50% yield) following the procedure described in example 34 (step A), starting with 6-bromopyridin-3-amine and 3,5-difluoro-4-(tributylstannyl)pyridine.

Workup

  1. customObtained (50% yield)

Sources & evidence

ORD record
ord-c4a5c136a52f45c5a1055d3fd4a0e082
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Linked notes

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