2-Amino-6-methoxy-3-nitropyridine → 2,3-Diamino-6-methoxypyridine
Reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([N+:10]([O-])=O)=[CH:5][CH:4]=1.[H][H]>CCO.[Pd]>[CH3:1][O:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([NH2:10])=[CH:5][CH:4]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
6-(Methyloxy)-3-nitro-2-pyridinamine (26 g, 129 mmol) was suspended in EtOH (500 ml) at room temperature under argon and then treated with palladium on carbon (15 g, 14.10 mmol) (10% paste). The reaction was stirred under 1 atmosphere of hydrogen overnight. The reaction was filtered through a Celite pad and the pad washed with EtOH (500 ml). EtOH was evaporated to afford the product as a purple oil (20.68 g, slightly impure).
Workup
- filtrationThe reaction was filtered through a Celite pad
- washthe pad washed with EtOH (500 ml)
- customEtOH was evaporated
Sources & evidence
- ORD record
- ord-88a8f48586f44d03bb48499e5776ae34
- Source dataset
- uspto-grants-2012_01
- Patent number
- US08097628B2
Reaction notes
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