2-Methoxyaniline → N~1~-(2-Methoxyphenyl)propane-1,3-diamine

Reaction equation

BrCCCC1C=CC=[C:7]2[C:8]([NH:10]C(=O)[C:6]=12)=O.[CH3:16][O:17][C:18]1[C:19]([NH2:24])=[CH:20][CH:21]=[CH:22][CH:23]=1>>[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[NH:24][CH2:6][CH2:7][CH2:8][NH2:10]

Participants

Reactant 2

HCID 70002-Methoxyaniline

HCID 21958088Bromopropylphthalimide

Product 1

HCID 15319685N~1~-(2-Methoxyphenyl)propane-1,3-diamineYield 33.5%

Procedure

By using 3-bromopropylphthalimide (25.0 g) and o-anisidine (10 g) as starting materials, the title compound (4.9 g) was obtained in the same manners as those of Reference Example 57, (1) and Reference Example 54, (4).

Sources & evidence

ORD record: ord-f4f5c14ea2af46fd9f6e6f687715679b
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08097708B2

Reaction notes

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