Benzenamine, 2-chloro-5-(trifluoromethyl)- → HCID 178522154, compound

HRID 421021Notes

Reaction equation

HRID 421021 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[Cl:12][C:13]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:14]=1[NH2:15]>>[Cl:12][C:13]1[CH:19]=[CH:18][C:17]([C:20]([F:22])([F:23])[F:21])=[CH:16][C:14]=1[NH:15][C:7](=[O:9])[C:6]1[CH:10]=[C:2]([Cl:1])[CH:3]=[N:4][C:5]=1[OH:11]

Participants

3

Reactant 2

HCID 8475Benzenamine, 2-chloro-5-(trifluoromethyl)-HCID 178524411HCID 178524411, compound

Product 1

HCID 178522154HCID 178522154, compoundYield 42.9%

Procedure

Using 5-chloro-2-hydroxynicotinic acid and 2-chloro-5-(trifluoromethyl)aniline as the raw materials, the same operation as the example 24 gave the title compound.

Sources & evidence

ORD record
ord-004f69de93db41a2b05a520bcd1a29da
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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