5-Iodosalicylic acid → N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-iodo-benzamide

HRID 421040

Reaction equation

HRID 421040 reaction equation
[I:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:26])([F:25])[C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[NH2:17]>>[F:12][C:13]([F:25])([F:26])[C:14]1[CH:15]=[C:16]([NH:17][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([I:1])[CH:3]=[CH:4][C:5]=2[OH:11])[CH:18]=[C:19]([C:21]([F:22])([F:24])[F:23])[CH:20]=1

Participants

3

Reactant 2

HCID 83885-Iodosalicylic acidHCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

Product 1

HCID 11190699N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-iodo-benzamideYield 62.2%

Procedure

Using 5-iodosalicylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-c73db785fcaa442d84a9fcf109ef49d6
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Linked notes

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