5-Nitrosalicylic acid → N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-nitro-benzamide

HRID 421041

Reaction equation

HRID 421041 reaction equation
[N+:1]([C:4]1[CH:12]=[C:8]([C:9]([OH:11])=O)[C:7]([OH:13])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:14][C:15]([F:28])([F:27])[C:16]1[CH:17]=[C:18]([CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[NH2:19]>>[F:14][C:15]([F:27])([F:28])[C:16]1[CH:17]=[C:18]([NH:19][C:9](=[O:11])[C:8]2[CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][C:7]=2[OH:13])[CH:20]=[C:21]([C:23]([F:24])([F:26])[F:25])[CH:22]=1

Participants

3

Reactant 2

HCID 73185-Nitrosalicylic acidHCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

Product 1

HCID 11741321N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-nitro-benzamideYield 57.2%

Procedure

Using 5-nitrosalicylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-272b3d6f791a4b248e02e5e1f30f7284
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Linked notes

Loading…