5-Chlorosalicylic Acid → 5-Chloro-2-hydroxy-N-[2,5-bis(trifluoromethyl)phenyl]benzamide

HRID 421089Notes

Reaction equation

HRID 421089 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:26])([F:25])[C:14]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:15]=1[NH2:16]>>[F:12][C:13]([F:25])([F:26])[C:14]1[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][C:15]=1[NH:16][C:7](=[O:9])[C:6]1[CH:10]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[OH:11]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 7198182,5-Bis(trifluoromethyl)aniline

Product 1

HCID 230703595-Chloro-2-hydroxy-N-[2,5-bis(trifluoromethyl)phenyl]benzamideYield 3.6%

Procedure

Using 5-chlorosalicylic acid and 2,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-3083954f21f54a2796a28d88dc59faf9
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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