5-Chlorosalicylic Acid → 5-Chloro-N-[2-fluoro-3-(trifluoromethyl)phenyl]-2-hydroxybenzamide

HRID 421094

Reaction equation

HRID 421094 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]1[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:17]=[CH:16][C:14]=1[NH2:15]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:15][C:14]1[CH:16]=[CH:17][CH:18]=[C:19]([C:20]([F:21])([F:22])[F:23])[C:13]=1[F:12])=[O:9]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 1455693-Amino-2-fluorobenzotrifluoride

Product 1

HCID 178601615-Chloro-N-[2-fluoro-3-(trifluoromethyl)phenyl]-2-hydroxybenzamideYield 71.7%

Procedure

Using 5-chlorosalicylic acid and 2-fluoro-3-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-4b7aa17251374474a1f68ee68498a675
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Linked notes

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