5-Bromosalicylic acid → 5-Bromo-N-[2-chloro-4-(trifluoromethyl)phenyl]-2-hydroxybenzamide

Reaction equation

[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:14]=1[NH2:15]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:15][C:14]1[CH:16]=[CH:17][C:18]([C:20]([F:21])([F:22])[F:23])=[CH:19][C:13]=1[Cl:12])=[O:9]

Participants

Reactant 2

HCID 69725-Bromosalicylic acid

HCID 1620012-Chloro-4-trifluoromethylaniline

Product 1

HCID 178602905-Bromo-N-[2-chloro-4-(trifluoromethyl)phenyl]-2-hydroxybenzamideYield 34.9%

Procedure

Using 5-bromosalicylic acid and 2-chloro-4-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record: ord-752ab556dff24b95aaf3f20eaa2c0335
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08097759B2

Reaction notes

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