Tert-butyl 4-[2-(4-methanesulfonyl-phenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate → HCID 67083133, compound

HRID 42157

Reaction equation

HRID 42157 reaction equation
[CH3:1][S:2]([C:5]1[CH:31]=[CH:30][C:8]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[CH2:22][CH2:21][N:20]([C:23](OC(C)(C)C)=O)[CH2:19][CH2:18]3)=[CH:13][N:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH2:32]([C:37]1[CH:38]=[N:39]C(Br)=[N:41][CH:42]=1)[CH2:33][CH2:34][CH2:35][CH3:36]>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[CH2:22][CH2:21][N:20]([C:23]4[N:41]=[CH:42][C:37]([CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])=[CH:38][N:39]=4)[CH2:19][CH2:18]3)=[CH:13][N:12]=2)=[CH:30][CH:31]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 44819975Tert-butyl 4-[2-(4-methanesulfonyl-phenoxymethyl)pyridin-5-yl]piperidine-1-carboxylateHCID 86654266HCID 86654266, compound

Product 1

HCID 67083133HCID 67083133, compound

Procedure

The title compound was prepared from tert-butyl 4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate (Example 1) (50 mg, 0.11 mmol) and 5-pentyl-2-bromopyrimidine (37 μL, 0.22 mmol) following a procedure analogous to that in Example 48 as a white crystal (35 mg, yield 64%).

Sources & evidence

ORD record
ord-e8436764dc3747dababb18eb91fd24a0
Source dataset
uspto-grants-2013_09
Patent number
US08536176B2

Linked notes

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