Quetiapine → HCID 131729402, compound

HRID 421570

Reaction equation

HRID 421570 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]1([CH3:55])[CH:33]=[CH:32][C:31]([C:34]([C@@:36]([C:52]([OH:54])=[O:53])([OH:51])[C@@:37]([C:42]([C:44]2[CH:49]=[CH:48][C:47]([CH3:50])=[CH:46][CH:45]=2)=[O:43])([OH:41])[C:38]([OH:40])=[O:39])=[O:35])=[CH:30][CH:29]=1>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]1([CH3:55])[CH:33]=[CH:32][C:31]([C:34]([C@@:36]([C:52]([O-:54])=[O:53])([OH:51])[C@@:37]([C:42]([C:44]2[CH:45]=[CH:46][C:47]([CH3:50])=[CH:48][CH:49]=2)=[O:43])([OH:41])[C:38]([O-:40])=[O:39])=[O:35])=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 5002QuetiapineHCID 29414711Di-para-toluoyl-L-tartaric acid

Product 1

HCID 131729402HCID 131729402, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Quetiapine free base (3.0 g) was dissolved in acetone (30 ml) at room temperature. To this solution was added di-p-toluoyl-L-tartaric acid (1.52 g) at 30 to 35° C. The resulting mass heated to reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.62 g).

Workup

  1. temperatureThe resulting mass heated
  2. temperatureto reflux
  3. temperaturemaintained for 30 minutes
  4. distillationThis was followed by the distillation of acetone
  5. customobtained solid
  6. customwas further dried under vacuum

Sources & evidence

ORD record
ord-06dbf6660c6847878637dcbfbbfbcc4f
Source dataset
uspto-grants-2012_01
Patent number
US08101597B2

Linked notes

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