3-(3-Amino-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane → HCID 86086918, compound

HRID 422294

Reaction equation

HRID 422294 reaction equation
[CH2:1]1[CH:5]2[CH:6]([C:8]3[O:12][N:11]=[C:10](N)[N:9]=3)CN(C2)[CH2:2]1.[Cl:14][C:15]1[C:16]([CH3:30])=[C:17](C2C=CC(NO)=CC=2)[CH:18]=[CH:19][C:20]=1N>>[CH2:6]([C:8]1[O:12][N:11]=[C:10]([C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([Cl:14])[C:16]=2[CH3:30])[N:9]=1)[CH2:5][C:1]#[CH:2]

Participants

3

Reactant 2

HCID 1639383-(3-Amino-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptaneHCID 87101445HCID 87101445, compound

Product 1

HCID 86086918HCID 86086918, compoundYield 46%

Procedure

According to the general protocol for oxadiazole synthesis described in Example 40(C) the conversion of 3-chloro-N′-hydroxy-2-methylbenzidine (628 mg, 3.4 mmol) afforded 387 mg of 5-(but-3-ynyl)-3-(3-chloro-2-methylphenyl)-1,2,4-oxadiazole (Yield: 46%) as yellow oil.

Sources & evidence

ORD record
ord-4feea008220d476d99fb328136536254
Source dataset
uspto-grants-2012_01
Patent number
US08101637B2

Linked notes

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