3-(Trifluoromethyl)piperidine → 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine

HRID 423165

Reaction equation

HRID 423165 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[C:10](F)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4].[F:13][C:14]([F:22])([F:21])[CH:15]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:16]1>C1(C)C=CC=CC=1>[CH2:1]([O:5][C:6]1[CH:11]=[C:10]([N:17]2[CH2:18][CH2:19][CH2:20][CH:15]([C:14]([F:22])([F:21])[F:13])[CH2:16]2)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4]

Participants

4

Reactant 2

HCID 27607763-(Trifluoromethyl)piperidineHCID 596619694-(2-Butynyloxy)-6-fluoropyrimidine

Product 1

HCID 576729514-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.2 g of 4-(2-butynyloxy)-6-fluoropyrimidine and 0.15 g of 3-trifluoromethylpiperidine are added to 1 ml of toluene, then the mixture is stirred at room temperature for 30 minutes. Then the reaction mixture is subjected to silica gel column chromatography to obtain 4-(2-butynyloxy)-6-(3-trifluoromethylpyperidino)pyrimidine (referred as the present compound (10) hereinafter).

Sources & evidence

ORD record
ord-396961e1920d455cb9aea8f8df2fdd63
Source dataset
uspto-grants-2012_01
Patent number
US08101753B2

Linked notes

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