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HCID 58275259, compound → HCID 58275500, compound

HRID 42330
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Reaction equation

HRID 42330 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[C:13]([NH:26][CH2:27][C:28]4[CH:33]=[CH:32][C:31]([S:34]([NH2:37])(=[O:36])=[O:35])=[CH:30][C:29]=4[C:38](F)(F)F)[N:14]=[C:15]([NH:18][C:19]4([C:22]([F:25])([F:24])[F:23])[CH2:21][CH2:20]4)[C:16]=3[N:17]=2)=[CH:4][CH:3]=1.ClC1C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.FC1C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.ClC1C=C(C(NC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C)C=CC=1S(N)(=O)=O.FC1C=C(CCNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.ClC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1S(N)(=O)=O.FC1C=C(S(N)(=O)=O)C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=1.FC1C=CC(C2C=CC3N=C(NCC4C=CC(S(N)(=O)=O)=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.FC1C=CC(C2C=CC3N=C(NCCC4C=CC(S(N)(=O)=O)=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.FC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1NS(C)(=O)=O.FC1C=CC(C2C=CC3N=C(NCC4C=CC(C(F)(F)F)=C(NS(C)(=O)=O)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.ClC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1NS(C)(=O)=O.ClC1C=C(NS(C)(=O)=O)C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=1.FC1C=CC(C2C=CC3N=C(NCC4C=C(NS(C)(=O)=O)C=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[C:13]([NH:26][CH2:27][C:28]4[CH:33]=[CH:32][C:31]([S:34]([NH2:37])(=[O:36])=[O:35])=[CH:30][C:29]=4[CH3:38])[N:14]=[C:15]([NH:18][C:19]4([C:22]([F:23])([F:25])[F:24])[CH2:21][CH2:20]4)[C:16]=3[N:17]=2)=[CH:6][CH:7]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

15

Reactant 14

HCID 58275259HCID 58275259, compoundHCID 58275351HCID 58275351, compoundHCID 58275354HCID 58275354, compoundHCID 58275379HCID 58275379, compoundHCID 58275476HCID 58275476, compoundHCID 67161822HCID 67161822, compound
HCID 67162433HCID 67162433, compound
HCID 67162584HCID 67162584, compound
HCID 67163129HCID 67163129, compound
HCID 67163310HCID 67163310, compound
HCID 866536144-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-benzenesulfonamide
HCID 866536154-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-2-trifluoromethyl-benzenesulfonamide
HCID 86653616HCID 86653616, compound
HCID 86653617HCID 86653617, compound

Product 1

HCID 58275500HCID 58275500, compound

Procedure

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-3-trifluoromethyl-benzenesulfonamide; 2-Chloro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 2-Fluoro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 2-Chloro-4-{1-[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide; 2-Fluoro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide; 2-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 3-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-benzenesulfonamide; 4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-2-trifluoromethyl-benzenesulfonamide; N-(2-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide, N-(5-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-phenyl)-methanesulfonamide; N-(2-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide; N-(3-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide; N-(3-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-5-trifluoromethyl-phenyl)-methanesulfonamide.

Sources & evidence

ORD record
ord-98d0c834dbde43a1b53db3864cf37fc4
Source dataset
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08536187B2

Reaction notes

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