2-Bromo-4,5-difluorobenzoic acid → 2-Bromo-4,5-difluoro-1-(methoxymethoxymethyl)benzene

Reaction equation

[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](O)=[O:5].BrC1C=CC(Cl)=CC=1[CH2:21][O:22][CH2:23]OC>>[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[CH2:4][O:5][CH2:21][O:22][CH3:23]

Participants

Reactant 2

HCID 27827892-Bromo-4,5-difluorobenzoic acid

HCID 590246772-Bromo-5-chloro-1-(methoxymethoxymethyl)benzene

Product 1

HCID 667046802-Bromo-4,5-difluoro-1-(methoxymethoxymethyl)benzene

Procedure

This compound was made from 2-bromo-4,5-difluorobenzoic acid in the same manner as compound 18d: 1H NMR (300 MHz, CDCl3) δ (ppm) 3.42 (s, 3H), 4.57 (d, J=1.2 Hz, 2H), 4.76 (s, 2H), 7.3-7.5 (m, 2H).

Sources & evidence

ORD record: ord-9dbc7819d0174dbbbca588c2ec68a961
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106031B2

Reaction notes

Loading…