Potassium Hydroxide → HCID 178425335, compound

HRID 424688

Reaction equation

[F:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[SH:11][C:12]1[N:17]=[C:16]([OH:18])[CH:15]=[C:14]([OH:19])[N:13]=1.[OH-].[K+]>>[F:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][S:11][C:12]1[N:17]=[C:16]([OH:18])[CH:15]=[C:14]([OH:19])[N:13]=1

Participants

Reactant 3

HCID 14797Potassium Hydroxide

HCID 519062Benzene, 1-(bromomethyl)-2-fluoro-3-methyl-

HCID 178516656HCID 178516656, compound

Product 1

HCID 178425335HCID 178425335, compound

Procedure

The subtitle compound was prepared as a yellow solid by the method of Example 39 step i) using 2-fluoro-3-methylbenzyl bromide (7.0 g), 2-mercaptopyrimidine-4,6-diol (5.0 g) and potassium hydroxide (1.93 g). Yield: 8.36 g.

Sources & evidence

ORD record: ord-0059cbcf94d5405d81d1cc1443e86cda
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106063B2

Linked notes

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