Benzylamine → (3aR,6aS)-Tetrahydro-2-(phenylmethyl)cyclopenta[c]pyrrole-1,3(2H,3aH)-dione

Participants

Reaction Steps

A solution of benzylamine (6.4 mL) and tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione (8 gm) in tetrahydrofuran (28 mL) was heated under reflux for 18 hours. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate, and filtered through a pad of celite. Evaporation under reduced pressure gave crude (3aR,6aS)-2-benzyltetrahydrocyclopenta[c]pyrrole-1,3(2H,3 aH)-dione.

Provenance & Evidence