Thiourea → Methyl 2-amino-5-(4-fluorophenyl)-1,3-thiazole-4-carboxylate
Reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.[NH2:16][C:17]([NH2:19])=[S:18]>>[CH3:1][O:2][C:3]([C:4]1[N:16]=[C:17]([NH2:19])[S:18][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:15]Participants
3
Procedure
prepared by reaction of 3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methyl ester with thiourea. LC-MS: tR=0.75 min; [M+H]+=253.
Sources & evidence
- ORD record
- ord-2a2e31dfbe1d494cb5c968f25b8d5a12
- Source dataset
- uspto-grants-2012_01
- Patent number
- US08106215B2
Reaction notes
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