2-(3-Bromopropoxy)tetrahydro-2H-pyran → 6-(4-Fluorophenyl)-4-(2-furyl)-5-(4-pyridyl)-2-[3-(tetrahydropyran-2-yloxy)propyl]pyrazolo[3,4-b]pyridine

HRID 42624

Reaction equation

HRID 42624 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]3[NH:14][N:15]=[CH:16][C:11]3=[C:10]([C:17]3[O:18][CH:19]=[CH:20][CH:21]=3)[C:9]=2[C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)=[CH:4][CH:3]=1.Br[CH2:29][CH2:30][CH2:31][O:32][CH:33]1[CH2:38][CH2:37][CH2:36][CH2:35][O:34]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:22]3[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=3)=[C:10]([C:17]3[O:18][CH:19]=[CH:20][CH:21]=3)[C:11]3[C:12](=[N:14][N:15]([CH2:29][CH2:30][CH2:31][O:32][CH:33]4[CH2:38][CH2:37][CH2:36][CH2:35][O:34]4)[CH:16]=3)[N:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27779882-(3-Bromopropoxy)tetrahydro-2H-pyranHCID 670149746-(4-fluorophenyl)-4-(2-furyl)-5-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridine

Product 1

HCID 684444586-(4-Fluorophenyl)-4-(2-furyl)-5-(4-pyridyl)-2-[3-(tetrahydropyran-2-yloxy)propyl]pyrazolo[3,4-b]pyridine

Procedure

Following a similar procedure to that described in examples 6 and 7, but starting from 6-(4-fluorophenyl)-4-(2-furyl)-5-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridine (obtained in example 171) and 2-(3-bromopropoxy)tetrahydropyran, the desired compound was obtained.

Sources & evidence

ORD record
ord-8f37a0f7fc454d6eb93760b202ce5b41
Source dataset
uspto-grants-2013_09
Patent number
US08536194B2

Linked notes

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