Ethanethiol → 6-(Ethylthio)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

HRID 42697

Reaction equation

Cl[C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH:12]=[O:13].[CH2:14]([SH:16])[CH3:15]>>[CH2:14]([S:16][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH:12]=[O:13])[CH3:15]

Participants

Reactant 2

HCID 6343Ethanethiol

HCID 3199716-Chloro-5-formyl-1,3-dimethyluracil

Product 1

HCID 584843356-(Ethylthio)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

Procedure

The process described in Method D was followed. 6-Chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde (0.303 g, 1.50 mmol) and ethanethiol were used to obtain the title compound. The crude product was purified by column chromatography with a mixture of n-hexane:ethyl acetate (1:1) as the eluent.

Sources & evidence

ORD record: ord-dbafb17038e6410e997a1aa39eb95162
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08536210B2

Linked notes

Loading…