Sodium borohydride → (2-Isopropyl-6-methylphenyl)methanol
Reaction equation
[CH:1]([C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:5]=1[CH:6]=[O:7])([CH3:3])[CH3:2].[BH4-].[Na+]>CO>[CH:1]([C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:5]=1[CH2:6][OH:7])([CH3:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-isopropyl-6-methylbenzaldehyd (1.75 g, 10.8 mmol) in methanol (15 ml) was added sodium borohydride (0.35 g, 9.5 mmol) and the mixture was stirred 1 h. at room temperature. The solvent was evaporated under reduced pressure and to the residue was added hexane and water. The organic layer was separated and evaporated under reduced pressure to give 1.73 g (98%) of the title compound as an oil.
Workup
- customThe solvent was evaporated under reduced pressure and to the residue
- additionwas added hexane and water
- customThe organic layer was separated
- customevaporated under reduced pressure
Sources & evidence
- ORD record
- ord-e446b94faa7448ce83e2e8534874030c
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06313137B1
Reaction notes
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