Benzeneacetic acid, 4-bromo- → 2-[(4-Bromophenyl)acetamido]butyric acid isobutyl ester

HRID 428083

Reaction equation

HRID 428083 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 74654Benzeneacetic acid, 4-bromo-HCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 155476402-[(4-Bromophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I above and using 4-bromophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-bee918f01eec4dc1b7f6b60618dbecef
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Linked notes

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