p-Tolylacetic acid → N-[(4-methylphenyl)acetyl]alanine iso-butyl ester

HRID 428109

Reaction equation

HRID 428109 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=1)[CH:13]([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 248474p-Tolylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 53936136N-[(4-methylphenyl)acetyl]alanine iso-butyl ester

Procedure

Following General Procedure I above, and using 4-methylphenylacetic acid (Aldrich) and L-alanine iso-butyl ester (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-05fa498c4cec4d1aa21a39e8a203c47a
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Linked notes

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