HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Morpholinoethoxy)benzaldehyde → 3-Hydroxy-3-[4-[2-(4-morpholinyl)-ethoxy]-phenyl]-1-propyne
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Morpholinoethoxy)benzaldehyde | HCID 3719902 | — |
| Reactant | HCID 178462451 | HCID 178462451 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Hydroxy-3-[4-[2-(4-morpholinyl)-ethoxy]-phenyl]-1-propyne | HCID 18359221 | — |
Reaction Steps
3-Hydroxy-3-[4-[2-(4-morpholinyl)-ethoxy]-phenyl]-1-propyne was prepared according to Method A above from 4-[2-(4-morpholinyl)-ethoxy]-benzaldehyde (0.630 g, 2.68 mmol) (see below) in THF (20 mL) and ethynylmagnesium chloride (3.0 mmol, 6 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 492 mg, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313310B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-841638b967d8442f87b038aa1e22ece7 |
| Source note | uspto-grants-2001_11 |