rel-(2R,6S)-2,6-Dimethylpiperidine → (2R,6S)-2,6-dimethyl-1-(3-{[4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-4-yl]oxy}propyl)piperidine

HRID 429242

Reaction equation

HRID 429242 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[CH3:25][C@@H:26]1[CH2:31][CH2:30][CH2:29][C@H:28]([CH3:32])[NH:27]1>>[CH3:25][C@@H:26]1[CH2:31][CH2:30][CH2:29][C@H:28]([CH3:32])[N:27]1[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 641768rel-(2R,6S)-2,6-DimethylpiperidineHCID 22994486[4'-(3-Chloropropoxy)[1,1'-biphenyl]-4-yl](pyrrolidin-1-yl)methanone

Product 1

HCID 70141065(2R,6S)-2,6-dimethyl-1-(3-{[4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-4-yl]oxy}propyl)piperidine

Procedure

The product from Example 11A and (2R,6S)-2,6-dimethylpiperidine were processed as described in Example 10F to provide the title compound.

Sources & evidence

ORD record
ord-5776e4694b23475da398be011cde973e
Source dataset
uspto-grants-2001_11
Patent number
US06316475B1

Linked notes

Loading…