(4-Fluorophenyl)hydrazine → 5-Amino-1-(2,4-difluorophenyl)4-(6-quinolinoyl)-pyrazole

HRID 429385

Reaction equation

HRID 429385 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([CH2:13][C:14]#[N:15])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.F[C:17]1C=CC(NN)=CC=1.[F:25][C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=1[NH:33][NH2:34]>>[NH2:15][C:14]1[N:33]([C:27]2[CH:28]=[CH:29][C:30]([F:32])=[CH:31][C:26]=2[F:25])[N:34]=[CH:17][C:13]=1[C:11]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:1]=[CH:2][CH:3]=[CH:4]2)=[O:12]

Participants

4

Reactant 3

HCID 69982(4-Fluorophenyl)hydrazineHCID 588958(2,4-Difluoro-phenyl)-hydrazineHCID 222628073-Oxo-3-(quinolin-6-yl)propanenitrile

Product 1

HCID 222628175-Amino-1-(2,4-difluorophenyl)4-(6-quinolinoyl)-pyrazole

Procedure

Proceeding as described in Example 1, step 2, but replacing 2-(3-bromobenzoyl)acetonitrile with 2-(6-quinolinoyl)acetonitrile and substituting 4-fluorophenylhydrazine in step 3 with 2,4-difluorophenylhydrazine was obtained 5-amino-1-(2,4-difluorophenyl)-4-(6-quinolinoyl)-pyrazole.HCl I 17) (mpt. 220-259.2).

Sources & evidence

ORD record
ord-34e09b9b35784eadab395a328453260f
Source dataset
uspto-grants-2001_11
Patent number
US06316466B1

Linked notes

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