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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42945Generated: October 26, 2026

4-(Trifluoromethyl)cinnamic acid → (E)-N-[2-(5-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide

https://huagongshe.com/reaction/42945

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)cinnamic acidHCID 688070—
Reactant2-[5-(2-Methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamineHCID 67365050—
Product(E)-N-[2-(5-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamideHCID 42644150—

Reaction Steps

Following general procedure A followed by B, starting from 2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine and (E)-3-(4-trifluoromethyl-phenyl)-acrylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536209B2
Source datasetuspto-grants-2013_09
ORD IDord-6f8586ed24834be194983b527f58b4a3
Source noteuspto-grants-2013_09