Sodium methanethiolate → 5-chloro-2-methylsulfanylindan-1-one

HRID 431300

Reaction equation

HRID 431300 reaction equation
Br[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:11])[CH:8]=2)[C:3]1=[O:12].[CH3:13][S-:14].[Na+]>C(O)C>[Cl:11][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[C:3](=[O:12])[CH:2]([S:14][CH3:13])[CH2:10]2

Participants

4

Reactant 2

HCID 4378561Sodium methanethiolateHCID 113340692-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one

Product 1

HCID 99207715-chloro-2-methylsulfanylindan-1-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.98 g (4 mmol) of 2-bromo-5-chloroindan-1-one and 0.42 g (6 mmol) of sodium thiomethoxide were suspended in 5 ml of ethanol, treated in an ultrasonic bath for 30 minutes and then stirred at room temperature for 90 minutes. The reaction mixture was concentrated under reduced pressure and chromatographed on silica gel using toluene/ethyl acetate 10/1. The eluates were concentrated under reduced pressure, giving 5-chloro-2-methylsulfanylindan-1-one of melting point 90° C.

Workup

  1. additiontreated in an ultrasonic bath for 30 minutes
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customchromatographed on silica gel
  4. concentrationThe eluates were concentrated under reduced pressure

Sources & evidence

ORD record
ord-85d7dcc5c4784dd09fe04f0ab3a0c3c0
Source dataset
uspto-grants-2003_12
Patent number
US06657086B2

Linked notes

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