Chloroform → 1-t-Butyl-3,3-dibutyl-5,5-dimethyl-piperazin-2-on

Reaction equation

[CH3:1][C:2]([NH2:10])([CH3:9])[CH2:3][NH:4][C:5]([CH3:8])([CH3:7])[CH3:6].[CH2:11]([C:15]([CH2:17][CH2:18][CH2:19][CH3:20])=O)[CH2:12][CH2:13][CH3:14].[OH-:21].[Na+].[CH:23](Cl)(Cl)Cl>>[C:5]([N:4]1[CH2:3][C:2]([CH3:9])([CH3:1])[NH:10][C:15]([CH2:17][CH2:18][CH2:19][CH3:20])([CH2:11][CH2:12][CH2:13][CH3:14])[C:23]1=[O:21])([CH3:8])([CH3:7])[CH3:6]

Participants

Reactant 4

HCID 6212Chloroform

HCID 104055-Nonanone

HCID 14798Sodium Hydroxide

HCID 125809891,2-Propanediamine, N1-(1,1-dimethylethyl)-2-methyl-

Product 1

HCID 187605331-t-Butyl-3,3-dibutyl-5,5-dimethyl-piperazin-2-on

Procedure

In analogy to Example B21, 1,1-dimethyl-2-t-butylaminoethylamin, dibutylketon, chloroform and NaOH are reacted to give the title compound as a yellow oil.

Sources & evidence

ORD record: ord-d9d89c4300714effb20f702d5787f977
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06664353B2

Reaction notes

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