3,4-Difluoroaniline → 1-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

HRID 43343

Reaction equation

HRID 43343 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[F:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][C:22]=1[F:23])[NH2:19].FC1C=CC(NC2CCN(C(OC(C)(C)C)=O)CC2)=CC=1>>[F:15][C:16]1[CH:17]=[C:18]([NH:19][CH:2]2[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]2)[CH:20]=[CH:21][C:22]=1[F:23]

Participants

4

Reactant 3

HCID 774693,4-DifluoroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 16413902tert-Butyl 4-(4-fluoroanilino)piperidine-1-carboxylate

Product 1

HCID 225580331-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

Procedure

The title compound was prepared from 1,1-dimethylethyl 4-oxo-1-piperidinecarboxylate and 3,4-difluoroaniline using a method similar to that described for D1 although the crude product was purified by chromatography.

Workup

  1. customwas purified by chromatography

Sources & evidence

ORD record
ord-3edec24171bf45e297a6b2f415193f29
Source dataset
uspto-grants-2013_09
Patent number
US08536182B2

Linked notes

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