Methyl 2-iodoisonicotinate → 2-(3,4-Dichloro-phenyl)-isonicotinic acid methyl ester

HRID 433603

Reaction equation

HRID 433603 reaction equation
[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][N:7]=[C:6](I)[CH:5]=1.[Cl:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][C:18]=1[Cl:19]>>[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:16]2[CH:15]=[CH:14][C:13]([Cl:12])=[C:18]([Cl:19])[CH:17]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 196869Methyl 2-iodoisonicotinateHCID 27343303,4-Dichlorobenzeneboronic acid

Product 1

HCID 690406242-(3,4-Dichloro-phenyl)-isonicotinic acid methyl ester

Procedure

The title compound, MS: m/e=281.0 (M+) was obtained as a light brown solid (59% yield) by the reaction of 2-iodo-isonicotinic acid methyl ester with 3,4-dichlorophenyl boronic acid.

Sources & evidence

ORD record
ord-299fae61360646ddaeed1ff4fe734288
Source dataset
uspto-grants-2003_12
Patent number
US06667335B2

Linked notes

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