HCID 23444959, compound → Benzenamine, 3-(1,1-difluoroethyl)-4-fluoro-
Reaction equation
[F:1][C:2]([C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:6]=1[F:14])([F:4])[CH3:3]>CO>[F:4][C:2]([C:5]1[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:6]=1[F:14])([F:1])[CH3:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-(1,1-difluoro-ethyl)-1-fluoro-4-nitro-benzene (10.4 g, 50.6 mmol) in methanol (200 ml) palladium on carbon (10%, 4 g) was added and the resulting mixture was hydrogenated for 2 h at 20° C. After filtration of the catalyst the solvent was evaporated to yield the title compound as a yellow semi solid mass. (8.5 g, 96%). MS: m/e=175 (M+).
Workup
- filtrationAfter filtration of the catalyst the solvent
- customwas evaporated
Sources & evidence
- ORD record
- ord-f6cfa3ece53e4f2e990e07bf26b4eaf4
- Source dataset
- uspto-grants-2003_12
- Patent number
- US06667335B2
Reaction notes
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