Boron, trifluoro(methanol)-, (T-4)- → HCID 86584267, compound

HRID 433727

Reaction equation

HRID 433727 reaction equation
CO.B(F)(F)F.C([NH:10][C:11]1[C:12]([F:32])=[CH:13][C:14]([Cl:31])=[C:15]([CH:30]=1)[O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(=O)C>>[NH2:10][C:11]1[C:12]([F:32])=[CH:13][C:14]([Cl:31])=[C:15]([CH:30]=1)[O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

Participants

3

Reactant 2

HCID 11062313Boron, trifluoro(methanol)-, (T-4)-HCID 86584266HCID 86584266, compound

Product 1

HCID 86584267HCID 86584267, compound

Procedure

Into a boron trifluoride methanol complex methanol solution is added ethyl [2-(5-acetylamino-2-chloro-4-fluorophenoxy)phenoxy]acetate, and the mixture is heated while stirring. Thereafter, the reaction solution is concentrated, the residue is dissolved in ethyl acetate, and washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to obtain ethyl [2-(5-amino-2-chloro-4-fluorophenoxy)phenoxy]acetate [Intermediate compound A3-23].

Workup

  1. temperaturethe mixture is heated
  2. concentrationThereafter, the reaction solution is concentrated
  3. dissolutionthe residue is dissolved in ethyl acetate
  4. washwashed with saturated aqueous sodium bicarbonate
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-33db2df52e6946c8b20f6fd6038ad6ce
Source dataset
uspto-grants-2003_12
Patent number
US06667413B2

Linked notes

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