Acetyl chloride → Benzeneethanol, alpha-methyl-, 1-acetate

HRID 434371

Reaction equation

HRID 434371 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[C:5]1([CH2:11][CH:12]([OH:14])[CH3:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CCOCC>[C:1]([O:14][CH:12]([CH3:13])[CH2:11][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 941851-Phenyl-2-propanol

Product 1

HCID 16457Benzeneethanol, alpha-methyl-, 1-acetate

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Acetyl chloride (16.7 g) in dry ether (50 ml) was added dropwise to a stirred solution of 1-phenylpropan-2-ol (26.4 g) in dry ether (250 ml). The mixture was refluxed for 2 h, washed with sodium bicarbonate solution, dried (MgSO4) and evaporated to a colourless oil (27.5 g).

Workup

  1. temperatureThe mixture was refluxed for 2 h
  2. washwashed with sodium bicarbonate solution
  3. dry with materialdried (MgSO4)
  4. customevaporated to a colourless oil (27.5 g)

Sources & evidence

ORD record
ord-503077e2db97420c8662fa1b6b958cd4
Source dataset
uspto-grants-1983_08
Patent number
US04396627

Linked notes

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