Sodium Hydroxide → 1-(4-Acetylphenyl) propan-2-ol

Reaction equation

C([O:4][CH:5]([CH3:16])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=1)(=O)C.[OH-].[Na+]>>[C:13]([C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH:5]([OH:4])[CH3:16])=[CH:8][CH:9]=1)(=[O:15])[CH3:14]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 204938272-Acetoxy-1-(4-acetylphenyl)propane

Product 1

HCID 225984461-(4-Acetylphenyl) propan-2-olYield 104.4%

Procedure

2-Acetoxy-1-(4-acetylphenyl) propane (4.5 g) was heated for 2 hours in refluxing 2 N sodium hydroxide solution. The mixture was allowed to cool and the product was extracted into ether. Evaporation of the dried (MgSO4) extracts gave an oil (3.8 g).

Workup

temperatureto cool
extractionthe product was extracted into ether
customEvaporation of the
dry with materialdried (MgSO4)

Sources & evidence

ORD record: ord-f3d02f20e0444b7eb09a5c9a270b63d0
Source dataset: uspto-grants-1983_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04396627

Reaction notes

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