Phenyl isocyanate → HCID 12893792, compound

HRID 434457

Reaction equation

HRID 434457 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[N:4][CH:3]=1.[C:8]1([N:14]=[C:15]=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CC(C)=O>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15]([NH:14][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:16])=[CH:3][N:4]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 2984924-Aminopyridazine

Product 1

HCID 12893792HCID 12893792, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

200 mg. of 4-aminopyridazine was suspended in 50 ml. of acetone. To the resulting suspension, 1.2 times the amount of phenyl isocyanate theoretically calculated was added and the mixture then reacted at room temperature overnight. The crystals formed were taken out by filtration. By recrystallization from an excess of methanol, N-(4-pyridazinyl)-N'-phenylurea was obtained (yield, greater than 80%); melting point higher than 250° C.

Workup

  1. customthe mixture then reacted at room temperature overnight
  2. customThe crystals formed
  3. filtrationwere taken out by filtration
  4. customBy recrystallization from an excess of methanol

Sources & evidence

ORD record
ord-9e4ffc2c86184b5a96e1e505db8d9a70
Source dataset
uspto-grants-1983_08
Patent number
US04397678

Linked notes

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