Sodium Hydroxide → HCID 178519985, compound
Reaction equation
C[O:2][CH:3](OC)[C:4]1[NH:5][CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:8]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[F:12][C:9]([F:10])([F:11])[C:7]1[N:8]=[C:4]([CH:3]=[O:2])[NH:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
2 N sulfuric acid (20 ml) was added to 2-(dimethoxymethyl)-4-(trifluoromethyl)-1H-imidazole obtained in Example (33a) (720 mg, 3.43 mmol), and the mixture was stirred at 90° C. for one hour. The reaction solution was neutralized with a 1 N aqueous sodium hydroxide solution, followed by extraction with ethyl acetate. Then, the organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure, to obtain 0.376 g of the title compound as a white solid (67%).
Workup
- extractionfollowed by extraction with ethyl acetate
- washThen, the organic layer was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-f116ae624e084a38a2c47faa9fe69926
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536197B2
Reaction notes
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