Bromine → 2-Bromo-4-(hydroxymethyl)-2,4-dimethyl-3-pentanone
Reaction equation
[OH:1][CH2:2][C:3]([CH3:10])([CH3:9])[C:4](=[O:8])[CH:5]([CH3:7])[CH3:6].[Br:11]Br>C(Cl)(Cl)Cl>[Br:11][C:5]([CH3:7])([CH3:6])[C:4](=[O:8])[C:3]([CH3:10])([CH3:9])[CH2:2][OH:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred, refluxing solution of 69 g. (0.48 mole) of 1-hydroxy-2,2,4-trimethylpentan-3-one in 500 ml. of chloroform was added dropwise a solution of 77 g. (0.48 mole) bromine in 100 ml. of chloroform. When the addition was completed the mixture was stirred at reflux for one hour, allowed to cool and stand overnight at room temperature. Evaporation of solvent at reduced pressure afforded 127 g. of product which was used in the next step without purification.
Workup
- temperatureTo a stirred, refluxing solution of 69 g
- additionWhen the addition
- temperatureat reflux for one hour
- temperatureto cool
- customEvaporation of solvent at reduced pressure
- customafforded 127 g
- customof product which was used in the next step without purification
Sources & evidence
- ORD record
- ord-1a4d3a05c68642a69617518c30a961cb
- Source dataset
- uspto-grants-1983_08
- Patent number
- US04399163
Reaction notes
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