Thionyl Chloride → 4-Chloro-5-ethyl-1H-imidazole-2-carbonyl chloride
Reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([C:9]([OH:11])=O)[NH:5][C:6]=1[CH2:7][CH3:8].S(Cl)([Cl:14])=O>>[Cl:1][C:2]1[N:3]=[C:4]([C:9]([Cl:14])=[O:11])[NH:5][C:6]=1[CH2:7][CH3:8]Participants
3
Conditions
- Temperature
- 75 °C
Procedure
4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained by the method described in Example (1d) (55 mg, 0.29 mmol) was dissolved in thionyl chloride (1.5 mL), and the mixture was stirred at 75° C. for 50 minutes. The reaction solution was concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.
Workup
- concentrationThe reaction solution was concentrated under reduced pressure
- customThe resulting compound was used for the next reaction without purification
Sources & evidence
- ORD record
- ord-97e94a26a3554dc48ecdb2e16e7f084b
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536197B2
Reaction notes
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