(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile → Diisopropylether hexane

Temperature

20 °C

Using the procedure of Step A of Example 7, 1.9 g of (1R, trans) 2,2-dimethyl-3-(4',4'-dibromo-buta-1',3'-dienyl)-cyclopropane-1-carboxylic acid chloride and 6.11 g of (S)α-cyano-3-phenoxy-benzyl alcohol were stirred for 17 hours at 20° C. and the mixture was poured into 200 ml of water with stirring. The decanted aqueous phase was extracted with benzene and the organic phase was washed with 0.1 N hydrochloric acid and then with water, was dried and evaporated to dryness under reduced pressure to obtain 15.4 g of raw product. The latter was chromatographed twice over silica gel and was eluted first with a 9-1 hexane-ethyl acetate mixture and then with an 8-2 hexane-isopropyl ether mixture to obtain 4.4 g of product which was crystallized from a 1-1 hexane-isopropyl ether mixture to obtain 2.2 g of (S)α-cyano-3-phenoxy-benzyl (1R,trans) 2,2-dimethyl-3-(4',4'-dibromo-buta-1',3'-dienyl)-cyclopropane-1-carboxylate melting at 110° C. and having a specific rotation of [α]D20 =+116°±1° (c=1% in benzene).

1. stirringwith stirring
2. extractionThe decanted aqueous phase was extracted with benzene
3. washthe organic phase was washed with 0.1 N hydrochloric acid
4. dry with materialwith water, was dried
5. customevaporated to dryness under reduced pressure
6. customto obtain 15.4 g of raw product
7. customThe latter was chromatographed twice over silica gel
8. washwas eluted first with a 9-1 hexane-ethyl acetate mixture

ORD record

ord-21b6bcf6d08c4ff5aae096b882fb1156

Source dataset

uspto-grants-1983_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04401673