HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → alpha-Hydroxy-beta-Phenoxy-N-(1-Methylethyl)-3-Chlorobenzenepropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | N-(1-methylethyl)-3-(3-chlorophenyl)-2-oxiranecarboxamide | HCID 13041335 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | alpha-Hydroxy-beta-Phenoxy-N-(1-Methylethyl)-3-Chlorobenzenepropanamide | HCID 13041346 | — |
Reaction Steps
This compound was prepared from N-(1-methylethyl)-3-(3-chlorophenyl)-2-oxiranecarboxamide (7.2 g.), phenol (3.0 g.), sodium hydride (50% oil dispersion, 1.6 g.), 18-crown-6 (0.9 g.) and acetonitrile (250 ml.) as described in Example 12. The crude product was recrystallized from ether. The compound melted at 160°-162°, and weighed 1.7 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04401832 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-36de2296413e41dfb4560091010942ff |
| Source note | uspto-grants-1983_08 |