7,15-Diazadispiro[5.1.5.3]hexadecane-14,16-dione → 7,15-Diazadispiro[5.1.5~8~.3~6~]hexadecane

Reaction equation

C[CH:2]1[C:7]2([CH2:18][NH:17][CH2:16][C:9]3([CH2:14][CH2:13][CH2:12][CH2:11][CH:10]3C)[NH:8]2)[CH2:6][CH2:5][CH2:4][CH2:3]1.C1C2(C(=O)NC(=O)C3(CCCCC3)N2)CCCC1.CC1C2(C(=O)NC(=O)C3(CCCCC3C)N2)CCCC1>>[CH2:2]1[C:7]2([CH2:18][NH:17][CH2:16][C:9]3([CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]3)[NH:8]2)[CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

Reactant 3

HCID 122347397,15-Diazadispiro[5.1.5.3]hexadecane-14,16-dione

HCID 20334465HCID 20334465, compound

HCID 21454725HCID 21454725, compound

Product 1

HCID 155578697,15-Diazadispiro[5.1.5~8~.3~6~]hexadecane

Procedure

In a similar manner, 1,9-dimethyl-7,15-diazadispiro[5,1,5,3]hexadecane is prepared by substituting for 7,15-diazadispiro[5,1,5,3]hexadecane-14,16-dione an equivalent amount of 1,9-dimethyl-7,15-diazadispiro[5,1,5,3]hexadecane-14,16-dione.

Sources & evidence

ORD record: ord-044052d179794d5cb3b309a7bf521b19
Source dataset: uspto-grants-1977_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04007157

Reaction notes

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